New MaCCLAB paper published in Diabetes!

New MaCCLAB paper published in Diabetes!

Diabetes-Induced Cellular Senescence and Senescence-Associated Secretory Phenotype Impair Cardiac Regeneration and Function Independently of Age. Diabetes, 2022 May 1;71(5):1081-1098. doi: 10.2337/db21-0536 Marino…

New MaCCardio LAB article in Cell Death & Disease

New MaCCardio LAB article in Cell Death & Disease

Abstract. An overdose of Isoproterenol (ISO) causes acute cardiomyocyte (CM) dropout and activates the resident cardiac c-kitpos stem/progenitor cells (CSCs) generating a burst of new CM formation that replaces those lost to ISO. Recently, unsuccessful attempts to reproduce these findings using c-kitCre knock-in (KI) mouse models were reported.

MaCCardio LAB paper published in Nature

MaCCardio LAB paper published in Nature

Kitcre knock-in mice fail to fate-map cardiac stem cells Carla Vicinanza, Iolanda Aquila, Eleonora Cianflone, Mariangela Scalise, Fabiola Marino, Teresa…